Goku has the ‘immune card’ because he is the main character of the Dragon Ball series. But if you commit the following, Goku will lose his life forever.
Goku has died a few times in Dragon Ball, but he always finds a way to come back to life thanks to the power of the Dragon Balls, or in other words Goku has the ‘death immunity card’ because he is the main character of the series.
In reality, Saiyans are strong enough to survive catastrophic attacks and explosions, but Goku is not completely invincible. If you commit the following, Goku will lose his life forever.
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Died of illness
During the Cell Saga, Goku is susceptible to illness and can even die. Trunks goes back in time to warn Goku that, in the future, he will die from a heart disease caused by a virus, fatal even for a Saiyan. Goku wouldn’t be able to come back to life because the Dragon Balls don’t revive people who die of natural causes and the seeds of the gods don’t cure diseases.
Accordingly, Goku can die if he is infected again with this virus or by a similar disease. However, it is clear that Bulma or someone from the Capsule Corporation will try to create the drug to fight the disease and save his life.
Died of old age
Saiyans have a longer lifespan than Earthlings, but they are not immortal or eternal, so Goku could die of old age. However, their old age will last many years longer than that of normal people.
The Saiyan race ages more slowly and their youth lasts until they are 80 years old. This is shown very clearly at the end of Dragon Ball Z, as Goku and Vegeta have similar appearances while Bulma and Chi-Chi have aged a lot.
Possessing a longer lifespan, perhaps Goku will be able to live to be 200, 300 years old or longer.
Death in space
Although the Saiyans have fought outside the atmosphere several times, Goku and Vegeta are said to be unable to breathe in space. However, looking back at battles like Bardock vs Frieza and Goku vs Beerus, where they fought in space, this argument seems contradictory.
Therefore, we can assume that Saiyans can survive for a few minutes in space, but cannot survive as long as Frieza’s race.
When arriving on Namek by spaceship, Goku must wear a spacesuit while in space, showing that he cannot live long without air. If he falls into a situation where he cannot use teleportation to reach the ground, Goku will likely die from lack of air and radiation from space.
Oppose being revived
After Cell was defeated, Goku’s friends collected the Dragon Balls to revive him, but he preferred to stay in another world to train. Goku remained dead for 7 years until the threat of Majin Buu appeared on Earth, so Goku returned to join the fight.
Goku will only die forever if it is his own choice.
Destroyed by Zeno Sama or some God of Destruction
If Goku fights against the God of Destruction, he can be quickly destroyed by Hakai, like Beerus did to Zamatsu in Dragon Ball Super. However, his friendship with Zeno Sama saved him from the threat of any God of Destruction, as no god had the authority to confront him.
If Goku angered Zeno Sama, the story would be different. Zeno Sama can crush the entire universe without leaving a trace, so Goku will be killed forever unless someone uses the Super Dragon Balls to bring him back.
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